Which vaccine would be expected to produce a better immune response?

The live attenuated varicella vaccine is expected to produce a better immune response compared to the other vaccines listed. This can be attributed to the way live attenuated vaccines work. They are made from live viruses that have been weakened (attenuated) so that they cannot cause disease but can still replicate in the body. This replication mimics a natural infection, which stimulates a robust immune response, including both the production of antibodies and the activation of T-cells, leading to long-lasting immunity.

In contrast, inactivated vaccines, like the inactivated polio vaccine and the Hep-A vaccine, use viruses that have been killed or inactivated, which typically result in a more limited immune response. The immune system is exposed to the proteins of the pathogen without the live virus, which means that the response is generally less vigorous.

Additionally, while the DTaP vaccine (which covers diphtheria, tetanus, and pertussis) is very effective, it is also an inactivated toxoid vaccine. Although it can generate a strong immune response, it does not tend to elicit the same level of activation of cellular immunity compared to live attenuated vaccines.

Therefore, the live attenuated varicella vaccine is likely to cause a