Which group should avoid live vaccines after vaccination?

Individuals receiving immune globulin should avoid live vaccines after vaccination due to the potential for immune modulation. Immune globulin, which is used to provide immediate passive immunity, can interfere with the immune response that is necessary for live vaccines to produce a robust protective effect. Live vaccines contain weakened forms of viruses or bacteria, prompting the immune system to build a response against the pathogen. If an individual is receiving immune globulin, the temporary antibodies provided may neutralize the live vaccine before it can elicit a proper immune response, leading to a decreased effectiveness of the vaccine.

In contrast, while individuals with egg allergies and those with a history of hives may have specific considerations regarding certain vaccines, these issues do not universally necessitate avoidance of live vaccines. Individuals with chronic conditions often need vaccines to prevent infections, and specific recommendations vary depending on the nature and severity of their conditions. Therefore, the unique immune-suppressing effects of immune globulin on the vaccination process make this group particularly distinct in their need to avoid live vaccines after such treatment.